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Correlation of Diffusion Tensor Imaging Indices with Clinical Finding in Cases of Acute Traumatic Cord Injury 2014

Category General Spine Chandrajit Prasad, MBBS, MD, DM
Jagathlal Gangadharan
Sharath Kumar
Purpose Patients with degenerative diseases of cervical spine are likely to develop acute cord injury following trivial trauma.. DTI of spinal cord is a promising tool in prognostication. Materials & Methods A prospective study was done to know the use of DTI in predicting outcome in acute deterioration of degenerative cervical spine disease. Cases presenting within 48 h of acute traumatic deterioration were included in the study. A screening MRI was done to know the extent of disease and cord damage. Using DTI, apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were calculated at the level of injury. Clinical correlation was done with ASIA and FIM scores. Results Five cases of cervical cord injury with a mean age of 46 ± 11 years were studied and were compared with three age matched controls. All the cases had a decrease in ADC values and increase in FA at the level of injury compared to other levels (p = 0.02) and to normal controls (p = 0.001). Conclusion ADC is a sensitive marker of acute cervical cord injury, in degenerative spine disease. References Leypold BG, Flanders AE, Burns AS. The early evolution of spinal cord lesions on MR imaging following traumatic spinal cord injury. Am J Neuroradiol. 2008;29(5):1012–1016