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DIFFUSION TENSOR EVALUATION OF THE NORMAL APPEARING WHITE MATTER OF CERVICAL SPINAL CORD IN MULTIPLE SCLEROSIS PATIENTS WITH AND WITHOUT SENSORIAL SYMPTOMS 2011

General Spine

Fernanda, Rueda Lopes, medical doctor
Fernanda, Miraldi, MD student, Non ASSR Member
Costa, A, Joao vitor, technician, Non ASSR Member
Romeu, C, Domingues, medical doctor, Non ASSR Member
Meng, Law, MD, PhD, Non ASSR Member
Emerson, L, Gasparetto, MD, PhD, Non ASSR Member

Poster

Purpose

Cervical spinal cord damage is quite common in Multiple sclerosis (MS). Although classical lesions are recognized as T2 hyperintensities, the normal appearing white matter damage (NAWM) is not well understood. Sensorial symptoms are the most common neurological manifestations in MS,but not always their existence is expalined by cervical spinal cord lesions. The aim of this study is to evaluate the correlation between sensory symptoms and NAWM damage using diffusion tensor MR imaging.

Methods & Materials

We compared 17 patients with MS (12 female and 5 male, mean age 36.5 years-old)including 9 patients with sensorial symptoms and 8 without any neurological symptom. MR imaging of the cervical spinal cord was conducted on a 1.5 MR scanner (Siemens, Avanto), including T2-WI and DTI images. Fractional anisotropy (FA), was calculated within regions of interest (ROIs) at the C2 level. The ROIâ