Devoted to diagnostic and interventional spine imaging and therapeutics


Diffusion tensor imaging in the evaluation of normal appearing white matter (NAWM) of the cervical spinal cord of relapsing-remitting multiple sclerosis and neuromyelitis optica patients 2011

General Spine

Fernanda, Rueda Lopes, medical doctor
Costa, A, Joao vitor, technician, Non ASSR Member
Fernanda, Miraldi, MD student, Non ASSR Member
Romeu, C, Domingues, MD, Non ASSR Member
Meng, Law, MD,PhD, Non ASSR Member
Emerson, L, Gasparetto, MD,PhD, Non ASSR Member



Multiple sclerosis (MS)and neuromyelitis optica (NO) are both demyelinating diseases,with spinal cord damage. Although conventional MRI lesion pattern is different between both of them, the WM damage extension is not clear. The aim is to evaluate NAWM damage pattern in NMO and MS patients using diffusion tensor MR imaging.

Methods & Materials

We compared 17 patients with RRMS and 8 patients with NMO (sex and age matched), including patients with and without sensorial symptoms.MR imaging of the cervical spinal cord was conducted on a 1.5 MR scanner (Siemens, Avanto). Fractional anisotropy (FA)and radial diffusivity (RD) were calculated within regions of interest (ROIs) at the C2 level. The ROIâ