Devoted to diagnostic and interventional spine imaging and therapeutics


Thoracic and lumbar osteolytic vertebral fractures caused by multiple myeloma treated with Balloon-Kyphoplasty or conservatively – 6 months prospective follow up 2009

Interventional Spine

Robert Pflugmacher, Dr.,
Anne-Marie Pobloth, , Non ASSR Member

Scientific Paper

Mentor Award: No

Institution where work was conducted

Charité - Universitätsmedizin Berlin, Centrum für Muskuloskeletale Chirurgie

Affiliation and Department

Charité - Universitätsmedizin Berlin, Centrum für Muskuloskeletale Chirurgie


Augustenburger Platz 1
Berlin, select one
Phone: +49 177 8033338


Balloon-Kyphoplasty is a minimally invasive stabilization procedure for the stabilization of osteoporotic and osteolytic vertebral fractures. The purpose of this prospective follow-up was to evaluate Balloon Kyphoplasty in comparison with a conservatively treated control group.

Methods & Materials

85 patients (52 males and 33 females) with 206 osteoporotic vertebral fractures were treated with Balloon Kyphoplasty, 48 (29 males and 19 females) with 80 vertebral fractures served as controls. We were able to have a 6 months follow up in 82 patients with 199 vertebrae treated with Balloon Kyphoplasty and 43 patients with 68 vertebral fractures treated conservatively. The effects on pain symptoms were measured on a self-reported Visual Analogue Scale (VAS) and the Oswestry score was documented to assess disability. Radiographic scans were performed pre- and postoperatively and after 3 and 6 months. The vertebral height and kyphosis angle were measured to assess the restoration of the sagittal alignment.


The median pain scores (VAS) improved significantly from pre- to post-intervention as did the Oswestry Disability Score (p<0.001), in the conservative group no significant changes could be documented. Balloon Kyphoplasty led to a significantly vertebral height restoration and correction of kyphotic deformity (p<0.05), in the conservative group significant further height loss and increase of kyphosis could be documented (p<0.001).


Balloon Kyphoplasty as an addition to oncologic treatment leads to a statistically significant reduction of pain status and improvement of physical function. Further, Balloon Kyphoplasty prevents a height loss and increase of kyphotic deformity.